Author/Authors :
Mrinal K. Kundu، نويسنده , , N. Sundar، نويسنده , , Srinivas K. Kumar، نويسنده , , Sujata V. Bhat، نويسنده , , Sukla Biswas، نويسنده , , Neena Valecha، نويسنده ,
Abstract :
Several Baylis-Hillman adducts and their derivatives were synthesized and evaluated as targeted potential anti-malarials. The compounds 4, 7 and 9 were found to have highest potency against P. falciparum in vitro. The in vivo test result of compound 4 and 9 against P. berghei demonstrated activity at 80 mg/Kg dose level.
