Title of article
Antimalarial activity of 3-hydroxyalkyl-2-methylene-propionic acid derivatives
Author/Authors
Mrinal K. Kundu، نويسنده , , N. Sundar، نويسنده , , Srinivas K. Kumar، نويسنده , , Sujata V. Bhat، نويسنده , , Sukla Biswas، نويسنده , , Neena Valecha، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1999
Pages
6
From page
731
To page
736
Abstract
Several Baylis-Hillman adducts and their derivatives were synthesized and evaluated as targeted potential anti-malarials. The compounds 4, 7 and 9 were found to have highest potency against P. falciparum in vitro. The in vivo test result of compound 4 and 9 against P. berghei demonstrated activity at 80 mg/Kg dose level.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1999
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790027
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