Title of article :
Synthesis and hypoglycemic effect of chrysin derivatives
Author/Authors :
Joon-Su Shin، نويسنده , , Kyoung-Soon Kim، نويسنده , , Myoung-Bohm Kim، نويسنده , , Jae-Hoon Jeong، نويسنده , , Bak-Kwang Kim، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 1999
Pages :
6
From page :
869
To page :
874
Abstract :
A series of 18 chrysin derivatives, prepared by alkylation and condensation, were fully characterized by NMR and other techniques and tested in vivo against the diabetes mellitus. Several modified compounds especially those with propyl, butyl, octyl and tolyl groups were found to have hypoglycemic effect on diabetec mice in spite of the fact that chrysin itself had inhibited insulin release by 40–60%. None of the test animals died at the maximum dose 500mg/kg and did not cause any significant change in general feature, water and food consumption, body weight and organ weight when we examined the acute oral toxicity of those compounds having significant hypoglycemic effect
Journal title :
Bioorganic & Medicinal Chemistry Letters
Serial Year :
1999
Journal title :
Bioorganic & Medicinal Chemistry Letters
Record number :
790053
Link To Document :
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