Author/Authors :
Keiko Yamamoto، نويسنده , , Hiroshi Ooizumi، نويسنده , , Kazuhiko Umesono، نويسنده , , Annemieke Verstuyf، نويسنده , , Roger Bouillon، نويسنده , , Hector F. DeLuca، نويسنده , , Toshimasa Shinki، نويسنده , , Tatsuo Suda، نويسنده , , Sachiko Yamada، نويسنده ,
Abstract :
The various biological activities of side-chain mobility restricted analogs, four diastereomers at C(20) and C(22) of 22-methyl-1α,25-dihydroxyvitamin D3, were evaluated. The relationship between structure and the various activities of the analogs was discussed in terms of the active space region concept that we previously suggested.
