Title of article
A new anti-tubulin agent containing the benzo[b]thiophene ring system
Author/Authors
Kevin G. Pinney، نويسنده , , A. Dawn Bounds، نويسنده , , Koren M. Dingeman، نويسنده , , Vani P. Mocharla، نويسنده , , George R. Pettit، نويسنده , , Ruoli Bai، نويسنده , , Ernest Hamel، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1999
Pages
6
From page
1081
To page
1086
Abstract
A new type of inhibitor of tubulin polymerization was discovered based on the 3-aroyl-2-arylbenzo[b]thiophene molecular skeleton. The lead compound in this series, 2-(4′-methoxyphenyl)-3-(3′,4′,5′-trimethoxybenzoyl)-6-methoxybenzo[b]thiophene1, inhibited tubulin polymerization, caused an increase in the mitotic index of CA46 Burkitt lymphoma cells, and inhibited the growth of several human cancer cell lines.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1999
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790095
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