Title of article
Synthesis and biological activity of trans-2,3-dihydroraloxifene
Author/Authors
Christopher R. Schmid، نويسنده , , Andrew L. Glasebrook، نويسنده , , Jerry W. Misner، نويسنده , , Gregory A. Stephenson، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1999
Pages
4
From page
1137
To page
1140
Abstract
The synthesis and biological evaluation of trans-2,3-dihydroraloxifene, 2, is described. The synthesis proceeds in 8 steps in 20% overall yield. Relative trans 2,3-stereochemistry is definitively established in ester 6, which is converted to the title compound via derivatization, Grignard addition, and deprotection. Evaluation in vitro shows the compound to be a potent selective estrogen receptor modulator (SERM).
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1999
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790106
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