Title of article
Preparation of pyrrolidine and isoxazolidine benzamidines as potent inhibitors of coagulation factor Xa
Author/Authors
John M. Fevig، نويسنده , , Joseph Buriak Jr.، نويسنده , , Pieter F. W. Stouten، نويسنده , , Robert M. Knabb، نويسنده , , Gilbert N. Lam، نويسنده , , Pancras C. Wong، نويسنده , , Ruth R. Wexler، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1999
Pages
6
From page
1195
To page
1200
Abstract
The serine protease factor Xa is a critical enzyme in the blood coagulation cascade. Recently, the inhibition of factor Xa has begun to emerge as an attractive strategy for the discovery of novel antithrombotic agents. Here we describe pyrrolidine and isoxazolidine benzamidines as novel and potent inhibitors of factor Xa.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1999
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790118
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