Title of article
Synthesis and biological activities of spiroheterocyclic growth hormone secretagogues
Author/Authors
Meng-Hsin Chen، نويسنده , , Patrick P. Pollard، نويسنده , , Arthur A. Patchett، نويسنده , , Kang Cheng، نويسنده , , Liente Wei، نويسنده , , Wanda W. -S. Chan، نويسنده , , Bridget Butler، نويسنده , , Thomas M. Jacks، نويسنده , , Roy G. Smith، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1999
Pages
6
From page
1261
To page
1266
Abstract
The synthesis and biological activities of a series of spiroheterocyclic growth hormone secretagogues are reported. Modification of the spiroindane part-structure of the prototypal secretagogue L-162,752 revealed that the spiroindane could be replaced with spirobenzodihydrothiophen derivatives to enhance not only in vitro potency but also oral activity. In this study non-aromatic D-2-amino-4-cyclohexylbutanoic analogs (8a–8d) were also identified to be active secretagogues.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1999
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790132
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