Author/Authors :
Joseph G. Harrison، نويسنده , , Christelle Frier، نويسنده , , Ronald Laurant، نويسنده , , Regina Dennis، نويسنده , , Kevin D. Raney، نويسنده , , Shankar Balasubramanian، نويسنده ,
Abstract :
The inhibition of human telomerase has been explored using peptide conjugated derivatives of a PNA pentamer directed at the RNA template of telomerase. It is demonstrated that the presence of cationic peptides at the N-terminus of the PNA results in enhanced inhibition of telomerase activity. Furthermore, inhibition depended on the specificity of PNA recognition.
