Author/Authors :
Robert J. Cherney، نويسنده , , Li Wang، نويسنده , , Dayton T. Meyer، نويسنده , , Chu-Biao Xue، نويسنده , , Elizabeth C. Arner، نويسنده , , Robert A. Copeland، نويسنده , , Maryanne B. Covington، نويسنده , , Karl D. Hardman، نويسنده , , Zelda R. Wasserman، نويسنده , , Bruce D. Jaffee، نويسنده , , Carl P. Decicco، نويسنده ,
Abstract :
Several macrocyclic, hydroxamate derivatives were synthesized and evaluated as inhibitors of matrix metalloproteinases (MMPs) and tumour necrosis factor-α (TNF-α) production. These macrocycles are anti-succinate based inhibitors linked from P1 to P2′. A variety of functionality was installed at the P1-P2′ linkage, which gave inhibitors that displayed excellent MMP inhibition and good TNF-α suppression.
