Title of article
Design, synthesis and structure-activity relationships of novel strychnine-insensitive glycine receptor ligands
Author/Authors
A. Cordi، نويسنده , , J. -M. Lacoste، نويسنده , , V. Audinot، نويسنده , , Millan M. Millan، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1999
Pages
6
From page
1409
To page
1414
Abstract
The in vitro activities of 3-hydroxy-imidazolidin-4-one derivatives demonstrated very restricted structure-activity relationships at the strychnine-insensitive glycine site of the NMDA receptor. The most active compound (3a) was completely unsubstituted and exhibited affinity and efficacy similar to that of D-cycloserine, the prototypical partial agonist at this site.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1999
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790160
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