Author/Authors :
Chester E. Rodriguez، نويسنده , , Haiyan Lu، نويسنده , , Trang T. Ding، نويسنده , , Karyn L. Mlodnosky، نويسنده , , Azar Dastgah، نويسنده , , Vinh Q. Lam، نويسنده , , C. Blake Nichols، نويسنده , , Clifford E. Berkman، نويسنده ,
Abstract :
Several N-thiophosphonyl-glutamates were found to be potent competitive inhibitors of a zinc-dependent glutamyl hydrolase, carboxypeptidase G (CPG). Weak inhibition exhibited by an analogous N-phosphonyl-glutamate suggests that the enhanced potency of the phosphonamidothioates is due to the presence of their sulfur ligand and its favorable interactions with active site features, presumably zinc(II).
