Title of article
Potential anxiolytic agents. 3. Novel A-ring modified pyrido[1,2-a]benzimidazoles
Author/Authors
Bruce E. Maryanoff، نويسنده , , Samuel O. Nortey، نويسنده , , James J. McNally، نويسنده , , Pauline J. Sanfilippo and، نويسنده , , David F. McComsey، نويسنده , , Barry Dubinsky، نويسنده , , Richard P. Shank، نويسنده , , Allen B. Reitz، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1999
Pages
6
From page
1547
To page
1552
Abstract
A variety of pyrido[1,2-a]benzimidazoles (PBIs) modified on the A-ring were prepared and evaluated for affinity to the benzodiazepine binding site on the GABA-A receptor and in animal models predictive of anxiolytic activity in humans. A-ring benzo-fused derivative 7 exhibited potent activity, as did the 6- and 7-pyrido compounds 3 and 4.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1999
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790186
Link To Document