Title of article
Design of scytalone dehydratase inhibitors as rice blast fungicides: (N-phenoxypropyl)-carboxamides
Author/Authors
Douglas B. Jordan، نويسنده , , Thomas A. Lessen، نويسنده , , Zdzislaw Wawrzak، نويسنده , , John J. Bisaha، نويسنده , , Troy C. Gehret، نويسنده , , Stephen L. Hansen، نويسنده , , Rand S. Schwartz، نويسنده , , Gregory S. Basarab، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1999
Pages
6
From page
1607
To page
1612
Abstract
Insights gained from a crystal structure of scytalone dehydratase led to the design of carboxamide inhibitors with a phenoxypropyl group substituted on the nitrogen atom. Potent enzyme inhibitors were synthesized around this motif, the best of which provided excellent control of rice blast disease in greenhouse assays and outdoor field trials.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1999
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790198
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