Author/Authors :
George W. Muller، نويسنده , , Roger Chen، نويسنده , , Shaei-Yun Huang، نويسنده , , Laura G. Corral، نويسنده , , Lu Min Wong، نويسنده , , Rebecca T. Patterson، نويسنده , , Yuxi Chen، نويسنده , , Gilla Kaplan، نويسنده , , David I. Stirling، نويسنده ,
Abstract :
Thalidomide, (1), is a known inhibitor of TNF-α release in LPS stimulated human PBMC. Herein we describe the TNF-α inhibitory activity of amino substituted analogs of thalidomide (1) and its isoindolin-1-one analog, EM-12 (2). The 4-amino substituted analogs were found to be potent inhibitors of TNF-α release in LPS stimulated human PBMC.
