Author/Authors :
Dennis Lee، نويسنده , , Jerry L. Adams، نويسنده , , Martin Brandt، نويسنده , , Walter E. DeWolf Jr.، نويسنده , , Paul M. Keller، نويسنده , , Mark A. Levy، نويسنده ,
Abstract :
An efficient strategy for the synthesis of a tetrapeptidyl substrate combinatorial array directed toward the caspases is described. Testing of this array with caspases 1 and 4 gave substrate hydrolytic profiles characteristic of each caspase, and permitted the identification of efficiently processed substrates. A comparison of this approach to that using a positional scanning library is presented.
