مرکز منطقه ای اطلاع رساني علوم و فناوري - 5-fluoro-2-methyl-N-[5-(5H-pyrrolo[2,1-c][1,4]benzodiazepine-10(11H)-yl carbonyl)-2-pyridinyl]benzamide (CL-385004) and analogs as orally active arginine vasopressin receptor antagonists

Title of article :

5-fluoro-2-methyl-N-[5-(5H-pyrrolo[2,1-c][1,4]benzodiazepine-10(11H)-yl carbonyl)-2-pyridinyl]benzamide (CL-385004) and analogs as orally active arginine vasopressin receptor antagonists

Author/Authors :

Venkatesan Aranapakam، نويسنده , , J. Donald Albright، نويسنده , , George T. Grosu، نويسنده , , Efren G. Delos Santos، نويسنده , , Peter S. Chan، نويسنده , , Joseph Coupet، نويسنده , , Xun Ru، نويسنده , , Trina Saunders، نويسنده , , H. Mazandarani، نويسنده ,

Issue Information :

روزنامه با شماره پیاپی سال 1999

Pages :

From page :

1737

To page :

1740

Abstract :

Synthesis and structure-activity relationships (SAR) of orally active arginine vasopressin (AVP) receptor antagonists are discussed. Potent and orally active AVP receptor antagonists are produced when ring A or VPA-985 (1) is replaced with a 3-pyridinyl unit (2).

Journal title :

Bioorganic & Medicinal Chemistry Letters

Serial Year :

1999

Journal title :

Bioorganic & Medicinal Chemistry Letters

Record number :

790223

Link To Document :

https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=790223