Title of article
Synthesis and preliminary biological evaluation of new α-amino amide anticonvulsants incorporating a dextromethorphan moiety
Author/Authors
Paolo Pevarello، نويسنده , , Gabriella Traquandi، نويسنده , , Alberto Bonsignori، نويسنده , , Robert A. McArthur، نويسنده , , Roberto Maj، نويسنده , , Carla Caccia، نويسنده , , Patricia Salvati، نويسنده , , Mario Varasi، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1999
Pages
6
From page
1783
To page
1788
Abstract
Dextromethorphan 1 is an effective neuroprotectant in animal models of epilepsy and ischemia but showed side-effects during clinical trials limiting its potential use in a clinical setting. Here we describe the enantioselective and enantiospecific syntheses and the initial in vitro and in vivo biological evaluation of new hybrid structures between 1 and a previously disclosed α-amino amide anticonvulsant (3).
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1999
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790232
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