Title of article
From histamine to imidazolylalkyl-sulfonamides: The design of a novel series of histamine H3-receptor antagonists
Author/Authors
Matthew J. Tozer، نويسنده , , Elaine A. Harper، نويسنده , , S. Barret Kalindjian، نويسنده , , Michael J. Pether، نويسنده , , Nigel P. Shankley، نويسنده , , Gillian F. Watt، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1999
Pages
6
From page
1825
To page
1830
Abstract
Histamine was converted to a selective histamine H3-receptor antagonist by capping the primary amine with 2-naphthalenesulfonyl chloride. Higher receptor affinity and lower variability in the data from the various bioassays were achieved with the 2-naphthalensulfonamides of histamine homologues.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1999
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790239
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