Author/Authors :
Isobel Bennett، نويسنده , , Nigel J. P. Broom، نويسنده , , Robert Cassels، نويسنده , , John S. Elder، نويسنده , , Nicky D. Masson، نويسنده , , Peter J. OʹHanlon، نويسنده ,
Abstract :
A series of β-diketone acrylate bioisosteres 4 of pseudomonic acid A 1 have been synthesized and evaluated for their ability to inhibit bacterial isoleucyl-tRNA synthetase and act as antibacterial agents. A number of analogues have excellent antibacterial activity. Selected examples were show to afford good blood levels and to be effective in a murine infection model.
