Title of article :
Discovery of a highly potent, functionally-selective muscarinic M1 agonist,WAY-132983 using rational drug design and receptor modelling
Author/Authors :
Annmarie L. Sabb، نويسنده , , G. Morris Husbands، نويسنده , , Joseph Tokolics، نويسنده , , Reinhardt P. Stein، نويسنده , , Rene P. Tasse، نويسنده , , Carl A. Boast، نويسنده , , John A. Moyer، نويسنده , , Magid Abou-Gharbia، نويسنده ,
Abstract :
Rational drug design utilizing a receptor homology model of the human muscarinic M1 receptor led to the discovery of the highly potent (Ki = 2 nM), efficacious, and in vivo functionally-selective M1 agonist, WAY-132983.
