Author/Authors :
Hiroshi Ohashi، نويسنده , , Akihiro Ueno، نويسنده , , Toyoo Nakao، نويسنده , , Junko Ito، نويسنده , , Kaname Kimura، نويسنده , , Masaharu Ishikawa، نويسنده , , Hiroyuki Kawai، نويسنده , , Hiroshi Iijima، نويسنده , , Tatsushi Osawa، نويسنده ,
Abstract :
Sulochrin, a metabolite of fungi, has been shown to have an inhibitory activity to eosinophil degranulation. A series of sulochrin derivatives substituted at ortho-positions to the 10-carbonyl group was examined the activity. The importance of alkylester at C-6 position and several chemical properties of substituted groups at ortho-positions to exhibit activity are described.
