Synthesis and cytotoxicity of analogues of the antibiotic BE 10988 inhibitors of DNA topoisomerase II
Author/Authors :
Marc-Olivier Catrycke، نويسنده , , Raymond Houssin، نويسنده , , Jean-Pierre Hénichart، نويسنده , , Bruno Pfeiffer، نويسنده , , Pierre Renard، نويسنده , , Laurent Dassonneville، نويسنده , , Christian Bailly، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 1999
Pages :
6
From page :
2025
To page :
2030
Abstract :
Indolequinone derivatives of the antitumour antibiotic BE 10988 were synthesized and evaluated for their cytotoxicity and action mechanism. The quinone system is essential to biological activity and the thiazole ring plays a major role in the poisoning of topoisomerase II.
