Title of article
Structure-activity relationships of pyrroloquinazolines as thrombin receptor antagonists
Author/Authors
Ho-Sam Ahn، نويسنده , , Leyla Arik، نويسنده , , George Boykow، نويسنده , , Duane A. Burnett، نويسنده , , Mary Ann Caplen، نويسنده , , Michael Czarniecki، نويسنده , , Martin S. Domalski، نويسنده , , Carolyn Foster، نويسنده , , Mahua Manna، نويسنده , , Andrew W. Stamford، نويسنده , , Yusheng Wu، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1999
Pages
6
From page
2073
To page
2078
Abstract
A series of pyrroloquinazolines has been discovered that represent novel small molecule inhibitors of the intramolecular ligand of the thrombin receptor. Analogs were prepared to study the structure-activity relationships of substitution at the N1, N3, and N7 positions of the heterocycle. Compounds 4e and 4f have been identified with IC50ʹs of 56 and 52 nM, respectively.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1999
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790287
Link To Document