Author/Authors :
Ho-Sam Ahn، نويسنده , , Leyla Arik، نويسنده , , George Boykow، نويسنده , , Duane A. Burnett، نويسنده , , Mary Ann Caplen، نويسنده , , Michael Czarniecki، نويسنده , , Martin S. Domalski، نويسنده , , Carolyn Foster، نويسنده , , Mahua Manna، نويسنده , , Andrew W. Stamford، نويسنده , , Yusheng Wu، نويسنده ,
Abstract :
A series of pyrroloquinazolines has been discovered that represent novel small molecule inhibitors of the intramolecular ligand of the thrombin receptor. Analogs were prepared to study the structure-activity relationships of substitution at the N1, N3, and N7 positions of the heterocycle. Compounds 4e and 4f have been identified with IC50ʹs of 56 and 52 nM, respectively.
