Author/Authors :
Kuo-Long Yu، نويسنده , , Edward Ruediger، نويسنده , , Guangxiang Luo، نويسنده , , Christopher Cianci، نويسنده , , Stephanie Danetz، نويسنده , , Laurence Tiley، نويسنده , , Ashok K. Trehan، نويسنده , , Ivo Monkovic، نويسنده , , Bradley Pearce، نويسنده , , Alain Martel، نويسنده , , Mark Krystal، نويسنده , , Nicholas A. Meanwell، نويسنده ,
Abstract :
A novel series of quinolizidine salicylamides was synthesized as specific inhibitors of the H1 subtype of influenza A viruses. These inhibitors inhibit the pH-induced fusion process, thereby blocking viral entry into host cells. Compound 16 was the most active inhibitor in this series with an EC50 of 0.25 μg/mL in plaque reduction assay. The synthesis and the SAR of these compounds are discussed.
