Title of article
3-Alkyl-(5,5′-diphenyl)imidazolidinediones as new cannabinoid receptor ligands
Author/Authors
Martial Kanyonyo، نويسنده , , Sophie J. Govaerts، نويسنده , , Emmanuel Hermans، نويسنده , , Jacques H. Poupaert، نويسنده , , Didier M. Lambert، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1999
Pages
4
From page
2233
To page
2236
Abstract
Twenty-four 3-alkyl-(5,5′-diphenyl)imidazolidinediones were synthesized and evaluated as new cannabinoid receptor ligands. Three compounds exhibited a Ki value around 100 nM against [3H]-SR 141716A binding obtained from human CB1 transfected CHO cells membranes. The lack of change of affinity in the presence of a non hydrolyzable GTP analogue seems to indicate they are cannabinoid antagonists.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1999
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790317
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