Title of article
Increased antiviral activity of cyclic urea HIV protease inhibitors by modifying the P1/P1′ substituents
Author/Authors
Robert F. Kaltenbach III، نويسنده , , Ronald M. Klabe، نويسنده , , Beverly C. Cordova، نويسنده , , Steven P. Seitz، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1999
Pages
4
From page
2259
To page
2262
Abstract
A series of alkyl substituted P1/P1′ analogs was prepared in an attempt to increase translation of the 3-aminoindazole class of HIV protease inhibitors. Increasing the lipophilicity of the P1/P1′ residues dramatically improved translation of enzyme activity to antiviral activity in the whole cell assay.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1999
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790322
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