Title of article
Novel protein kinase C inhibitors: synthesis and PKC inhibition of β-substituted polythiophene derivatives
Author/Authors
Wei-Chu Xu، نويسنده , , Qin Zhou، نويسنده , , Curtis L. Ashendel، نويسنده , , Ching-Te Chang، نويسنده , , Ching-jer Chang، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1999
Pages
4
From page
2279
To page
2282
Abstract
A series of β-substituted polythiophene derivatives was synthesized through palladium-catalyzed coupling reaction. Their structure-protein kinase C (PKC) inhibitory activity relationship was studied. The carboxaldehyde and hydroxymethyl derivatives of α-terthiophene were potent PKC inhibitors (IC50 = 10−7 M).
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1999
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790326
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