Title of article :
Synthesis and dopamine receptor modulating activity of unsubstituted and substituted triproline analogues of -prolyl- -leucyl-glycinamide (PLG)
Author/Authors :
Paul W. Baures، نويسنده , , Ashish Pradhan، نويسنده , , William H. Ojala، نويسنده , , William B. Gleason، نويسنده , , Ram K. Mishra، نويسنده , , Rodney L. Johnson، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 1999
Abstract :
Triprolines Pro-Pro-Pro-NH2 (4), Pro-Pro- -Pro-NH2 (5), (6), and (7) were made as conformationally constrained analogues of Pro-Leu-Gly-NH2. Triprolines 4–6 produced significant increases in the high- and low-affinity state ratio (RH/RL) of the dopamine receptor, but only 4 was found to increase apomorphine induced rotations in 6-hydroxydopamine-lesioned rats.
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
