Author/Authors :
Robert M. Schelkun، نويسنده , , Po-Wai Yuen، نويسنده , , Thomas C. Malone، نويسنده , , David M. Rock، نويسنده , , Sally Stoehr، نويسنده , , Balazs Szoke، نويسنده , , Katalin Tarczy-Hornoch، نويسنده ,
Abstract :
Voltage activated calcium channel (VACC) blockers have been demonstrated to have utility in the treatment of stroke and pain. A series of aminomethyl substituted phenol derivatives has been identified with good functional activity and selectivity for N-type VACCʹs over sodium and potassium channels. The methods of synthesis and preliminary pharmacology are discussed herein.
