Author/Authors :
Michael G.N. Russell، نويسنده , , Margaret S. Beer، نويسنده , , Josephine A. Stanton، نويسنده , , Bindi Sohal، نويسنده , , Russell J. Mortishire-Smith، نويسنده , , José L. Castro، نويسنده ,
Abstract :
The conformational restriction of a (benzylamino)methyl substituted pyrrolidine to form 2,7-diazabicyclo[3.3.0]octanes has led to a series of compounds with high affinity at the h5-HT1D receptor as well as dramatically increased concentrations in the hepatic portal vein following oral administration.
