Author/Authors :
Seiichi Sato، نويسنده , , Yasuyo Suga، نويسنده , , Toshihiko Yoshimura، نويسنده , , Ryusuke Nakagawa، نويسنده , , Takashi Tsuji، نويسنده , , Ken Umemura، نويسنده , , Toshiwo Andoh، نويسنده ,
Abstract :
A series of methoxycarbonyl group modified nidulalin A analogs were synthesized to improve stability against esterases. The amide derivatives showed cytotoxic activity along with inhibitory activity against DNA topoisomerase II. Among the analogs, amide 9a exhibited antitumor activity in Colon 26 murine tumor model.
