Synthesis and SAR studies of 1-substituted-n-(4-alkoxycarbonypiperidin-1-yl)alkanes as potent antiarrhythmic agents

Synthesis and SAR studies of the title compounds have resulted in the identification of structural and physicochemical parameter (Vw) contributing for antiarrhythmic activity. Among the two most promising compounds 3a & 3b, the 3a has shown antiarrhythmic activity comparable to quinidine.