Combinatorial search of substituted β-cyclodextrins for phosphatase-like activity

Thirteen per-6-alkylamino-6-deoxy-β-cyclodextrin libraries (β-CD libraries) were generated by a solution-phase combinatorial synthesis starting from per-6-iodo-6-deoxy-β-CD and different combinations of eleven individual amine nucleophiles. Certain libraries showed the ability to hydrolyze p-nitrophenyl phosphate in the presence of Zn2+.