Author/Authors :
Andrzej W. Lipkowski، نويسنده , , Aleksandra Misicka، نويسنده , , Peg Davis، نويسنده , , Dagmar Stropova، نويسنده , , Jacqueline Janders، نويسنده , , Magdalena Lachwa، نويسنده , , Frank Porreca، نويسنده , , Henry I. Yamamura، نويسنده , , Victor J. Hruby، نويسنده ,
Abstract :
The synthesis and biological activity of two fragments of the very potent opioid peptide biphalin, showed that Tyr-D-Ala-Gly-Phe-NH-NH<-Phe is the minimal fragment necessary to express equal affinities and the same biological activity profile as the parent biphalin. The replacement of N′-Phe with other L- or D- lipophilic amino acids showed the possibility of modification of receptor efficacy of the analogues.
