Title of article
Bifunctional 2-naphthyl propargylic sulfones exhibiting high DNA intercalating and alkylating activity
Author/Authors
Wei-Min Dai، نويسنده , , Chun Wo Chow، نويسنده , , Guo-ling Zhou، نويسنده , , Atsushi Ishii، نويسنده , , Chi Wai Lau، نويسنده , , Quan Li، نويسنده , , Wataru Hamaguchi، نويسنده , , Sei-ichi Nishimoto، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1999
Pages
6
From page
2789
To page
2794
Abstract
A number of novel 2-naphthyl propargylic sulfones were synthesized as nucleic base alkylating agents. Extremely high DNA cleavage activity was observed for the sulfones with a free ω-hydroxyl group in the carbon chain in contrast to the ester conjugates possessing an additional intercalating unit.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1999
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790426
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