Title of article
Binding affinities of 3-(3-phenylisoxazol-5-yl)methylidene-1-azabicycles to acetylcholine receptors
Author/Authors
Kyung Il Choi، نويسنده , , Joo Hwan Cha، نويسنده , , Yong Seo Cho، نويسنده , , Ae Nim Pae، نويسنده , , Changbae Jin، نويسنده , , Juwon Yook، نويسنده , , Hyae Gyeong Cheon، نويسنده , , Daeyoung Jeong، نويسنده , , Jae Yang Kong، نويسنده , , Hun Yeong Koh، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1999
Pages
6
From page
2795
To page
2800
Abstract
A series of 3-(3-phenylisoxazol-5-yl)methylidene-1-azabicycles synthesized showed different binding characteristics to acetylcholine receptors depending on the substituents on the phenyl ring. Small polar substituents gave preferential binding affinity to nicotinic receptors, and large hydrophobic substituents to muscarinic receptors.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1999
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790427
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