Title of article
Design, synthesis and testing of amino-bicycloaryl based orally bioavailable thrombin inhibitors
Author/Authors
J. B. M. Rewinkel، نويسنده , , H. Lucas، نويسنده , , M. J. Smit، نويسنده , , A. B. J. Noach، نويسنده , , T. G. van Dinther، نويسنده , , A. M. M. Rood، نويسنده , , A. J. S. M. Jenneboer، نويسنده , , C. A. A. van Boeckel، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1999
Pages
6
From page
2837
To page
2842
Abstract
Replacement of the highly basic benzamidine moiety with moderate basic amino-bicycloaryl moieties in a series of thrombin inhibitors related to NAPAMP provided potent enzyme inhibition and significant improvements in membrane transport and oral bioavailability.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1999
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790436
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