Author/Authors :
Patrick Laurin، نويسنده , , Didier Ferroud، نويسنده , , Laurent Schio، نويسنده , , Michael Klich، نويسنده , , Claudine Dupuis-Hamelin، نويسنده , , Pascale Mauvais، نويسنده , , Patrice Lassaigne، نويسنده , , Alain Bonnefoy، نويسنده , , Branislav Musicki، نويسنده ,
Abstract :
Two series of aminosubstituted coumarins were synthesised and evaluated in vitro as inhibitors of DNA gyrase and as potential antibacterials. Novel novobiocin-like coumarins, 4-(dialkylamino)-methylcoumarins and 4-((2-alkylamino)ethoxy)coumarins, were discovered as gyrase B inhibitors with promising antibacterial activity in vitro.
