Title of article
The synthesis and biological evaluation of non-peptidic matrix metalloproteinase inhibitors
Author/Authors
Fionna M. Martin، نويسنده , , R. Paul Beckett، نويسنده , , Claire L. Bellamy، نويسنده , , Paul F. Courtney، نويسنده , , Stephen J. Davies، نويسنده , , Alan H. Drummond، نويسنده , , Rory Dodd، نويسنده , , Lisa M. Pratt، نويسنده , , Sanjay R. Patel، نويسنده , , Michelle L. Ricketts، نويسنده , , Richard S. Todd، نويسنده , , Andrew R. Tuffnell، نويسنده , , John W. S. Ward، نويسنده , , Mark Whittaker، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1999
Pages
6
From page
2887
To page
2892
Abstract
Novel sulfonamide matrix metalloproteinase inhibitors of general formula (9) were synthesised by a route involving a stereoselective conjugate addition reaction. Enzyme selectivity was found to be dependant on the nature of the sulfonamide substituents. Compounds (9f, 9q) are potent selective collagenase inhibitors with good oral bioavailability.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1999
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790447
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