Author/Authors :
Jeewoo Lee، نويسنده , , Shin-Ung Park، نويسنده , , JIYOUNG KIM ، نويسنده , , Jin-Kwan Kim، نويسنده , , Jiyoun Lee، نويسنده , , Uhtaek Oh، نويسنده , , Victor E. Marquez، نويسنده , , Maryam Beheshti، نويسنده , , Qiming J. Wang، نويسنده , , Shayan Modarres، نويسنده , , Peter M. Blumberg، نويسنده ,
Abstract :
A series of 3-acyloxy-2-phenalkylpropyl amides and esters of homovanillic acid were designed and synthesized as vanilloid receptor agonists containing the three principal pharmacophores of resiniferatoxin. Amide analogues 23, 5 and 11 were found to be potent agonists in vanilloid receptor assay both for ligand binding and for activation.
