Author/Authors :
Ramesh M. Kanojia، نويسنده , , L. William Murray، نويسنده , , Jeffrey Bernstein، نويسنده , , Jeffrey Fernandez، نويسنده , , Barbara D. Foleno، نويسنده , , Heather Krause، نويسنده , , Laura Lawrence، نويسنده , , Glenda Webb، نويسنده , , John F. Barrett، نويسنده ,
Abstract :
A series of 6-oxa isosteres of anacardic acids (6-higher alkyl/alkenyl-2-hydroxybenzoic acids) was synthesised and several members were discovered to be among the most potent inhibitors (IC50 values ≤ 5 μM) of the bacterial two-component regulatory systems, KinA/SpoOF and NRII/NRI, reported to date. The Gram-positive antibacterial activity in selected strains is also presented.
