Title of article :
First systematic chiral syntheses of two pairs of enantiomers with 3,5-dihydroxyheptenoic acid chain, associated with a potent synthetic statin NK-104
Author/Authors :
Mikio Suzuki، نويسنده , , Yoshinobu Yanagawa، نويسنده , , Hiroshi Iwasaki، نويسنده , , Hiroyasu Kanda، نويسنده , , Kazufumi Yanagihara، نويسنده , , Hiroo Matsumoto، نويسنده , , Yoshio Ohara، نويسنده , , Yukari Yazaki، نويسنده , , Ryozo Sakoda، نويسنده ,
Abstract :
First systematic chiral syntheses of two pairs of enantiomers with 3,5-dihydroxyheptenoic acid chain, associated with a potent synthetic statin NK-104 are reported. A pair of syn diol isomers (NK-104 and its enantiomer) was obtained efficiently by diastereomeric resolution. The synthesis of a pair of anti diol isomers (3-epimer and 5-epimer) was accomplished effectively by the asymmetric aldol reaction followed by anti stereoselective reduction as key steps. Their purity determinations were effected by chiral HPLC analysis.
