Title of article :
Synthesis and antitumor activity of water-soluble duocarmycin B1 prodrugs
Author/Authors :
Akira Asai، نويسنده , , Satoru Nagamura، نويسنده , , Eiji Kobayashi، نويسنده , , Katsushige Gomi، نويسنده , , Hiromitsu Saito، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 1999
Abstract :
The water-soluble duocarmycin B1 prodrugs such as glycoside 3, phosphate 4 and carbamate 5 were synthesized for improving biological and pharmaceutical profiles of duocarmycin. Among these prodrugs, N-methylpiperazinylcarbamoyl derivative 5 exhibited potent antitumor activity against several human tumors in vivo.
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
