Author/Authors :
William C. Shakespeare، نويسنده , , Regine S. Bohacek، نويسنده , , Surinder S. Narula، نويسنده , , Mihai D. Azimioara، نويسنده , , Ruth W. Yuan، نويسنده , , David C. Dalgarno، نويسنده , , Laura Madden، نويسنده , , Martyn C. Botfield، نويسنده , , Dennis A. Holt، نويسنده ,
Abstract :
A CuBr-mediated, regioselective cross-coupling between methyl 2,5-diiodobenzoate (4) and [(diethoxyphosphinyl)difluoromethyl]zinc bromide is reported. Palladium-catalyzed incorporation of an amino acid side chain, followed by subsequent modifications resulted in the rapid construction of 2. Compound 2 was designed to engage Cys188 of the Src SH2 domain, however, this was not observed spectroscopically.
