Author/Authors :
David G. Smith، نويسنده , , Andrew D. Gribble، نويسنده , , David Haigh، نويسنده , , Robert J. Ife، نويسنده , , Patrick Lavery، نويسنده , , Peter Skett، نويسنده , , Brian P. Slingsby، نويسنده , , Rachel Stacey، نويسنده , , Robert W. Ward، نويسنده , , Andrew-West، نويسنده ,
Abstract :
Aryl hydroxylamine derivatives have been synthesised that are some of the most potent inhibitors of hCMV protease prepared to date (IC50 14–60 nM). Mass spectrometry studies indicate that oxazinone derived hydroxylamines inhibit the enzyme by acylation of Ser132 whereas non-oxazinone derived hydroxylamines appear to inhibit via formation of a sulfinanilide at Cys138.
