Antiplatelet actions of aporphinoids from formosan plants

Seventeen aporphines were tested for antiplatelet activity. L-(+)-hernovine HCl and 7-hydroxydehydrothalicsimidine strongly inhibited platelet aggregation induced by adenosine 5′-diphosphate (ADP), arachidonic acid (AA), collagen, and platelet-activating factor (PAF). The latter showed the strongest antiplatelet activity with an IC50 of 70.4 μM against AA-induced platelet aggregation. Abstract Seventeen aporphines were tested for antiplatelet activity. L-(+)-hernovine HCl and 7-hydroxydehydrothalicsimidine strongly inhibited platelet aggregation induced by adenosine 5′-diphosphate (ADP), arachidonic acid (AA), collagen, and platelet-activating factor (PAF). The latter showed the strongest antiplatelet activity with an IC50 of 70.4 μM against AA-induced platelet aggregation.