Author/Authors :
K. R. C. Prakash، نويسنده , , Amir P. Tamiz، نويسنده , , Gian Luca Araldi، نويسنده , , Mei Zhang، نويسنده , , Kenneth M. Johnson، نويسنده , , Alan P. Kozikowski، نويسنده ,
Abstract :
A series of N-phenylalkyl-substituted tropane analogs of boat conformation was synthesized, and these tropanes were evaluated for their ability to inhibit high affinity uptake of dopamine (DA) and serotonin (5-HT) into striatal nerve endings (synaptosomes). Some of these compounds exhibit high affinity for the DA transporter with a 5-HT/DA transporter selectivity ratio of >50.
