Title of article
4-Pyridin-5-yl-2-(3,4,5-trimethoxyphenylamino)pyrimidines: Potent and selective inhibitors of ZAP 70
Author/Authors
David Moffat، نويسنده , , Peter Davis، نويسنده , , Martin Hutchings، نويسنده , , Jeremy Davis، نويسنده , , Daniel Berg، نويسنده , , Mark Batchelor، نويسنده , , James Johnson، نويسنده , , James OʹConnell، نويسنده , , Richard Martin، نويسنده , , Tom Carabbe، نويسنده , , Jean Delgado، نويسنده , , Martin Perry، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1999
Pages
6
From page
3351
To page
3356
Abstract
Activation of the tyrosine kinase ZAP 70 has been shown to be crucial to the transduction of the T-cell receptor signalling pathway, which leads ultimately to proliferation, cytokine gene expression and T-cell effector functions. A series of 2-phenylaminopyrimidines have been identified as potent and selective inhibitors of ZAP 701.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1999
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790535
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