Title of article
Novel synthetic analogs of the Pseudomonas autoinducer
Author/Authors
T. Kline، نويسنده , , J. Bowman، نويسنده , , B. H. Iglewski، نويسنده , , T. de Kievit، نويسنده , , Y. Kakai، نويسنده , , L. Passador، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1999
Pages
6
From page
3447
To page
3452
Abstract
Release of virulence factors in Pseudomonas aeruginosa is regulated by two N-acylhomoserine lactones, PAI-1 and PAI-2, that activate the respective transcription factors LasR and RhlR. With the goal of developing novel therapeutic agents, we synthesized constrained analogs of PAI-1 and evaluated them in P. aeruginosa. Two of the novel analogs bound to LasR and showed agonist activity in LasR stimulation of a lasI-lacZ reporter construct.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1999
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790553
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