Title of article
Design, synthesis and structure–activity relationship of a series of arginine aldehyde factor Xa inhibitors. Part 1: structures based on the ( )-Arg-Gly-Arg tripeptide sequence
Author/Authors
Charles K. Marlowe، نويسنده , , Uma Sinha، نويسنده , , Alice C. Gunn، نويسنده , , Robert M. Scarborough، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2000
Pages
4
From page
13
To page
16
Abstract
A series of arginine aldehyde inhibitors was designed as transition state (TS) analogues based on the known factor Xa specific substrate Cbz- -Arg-Gly-Arg-pNA. BnSO2-( )Arg-Gly-Arg-H (20) was found to be the most potent and selective inhibitor of factor Xa and prothrombinase activity in this series.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2000
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
790560
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